Micro-expression spotting is a fundamental step in the micro-expression analysis. This paper proposes a novel network based convolutional neural network (CNN) for spotting multi-scale spontaneous micro-expression intervals in long videos. We named the network as Micro-Expression Spotting Network (MESNet). It is composed of three modules. The first module is a 2+1D Spatiotemporal Convolutional Network, which uses 2D convolution to extract spatial features and 1D convolution to extract temporal features. The second module is a Clip Proposal Network, which gives some proposed micro-expression clips. The last module is a Classification Regression Network, which classifies the proposed clips to micro-expression or not, and further regresses their temporal boundaries. We also propose a novel evaluation metric for spotting micro-expression. Extensive experiments have been conducted on the two long video datasets: CAS(ME)2 and SAMM, and the leave-one-subject-out cross-validation is used to evaluate the spotting performance. Results show that the proposed MESNet effectively enhances the F1-score metric. And comparative results show the proposed MESNet has achieved a good performance, which outperforms other state-of-the-art methods, especially in the SAMM dataset.