The Coronavirus Disease 2019 (COVID-19) epidemic has become a global public health event. Medical staff around the world are nervously responding to the crisis, and their mental health problems deserve attention. To better know the differences in the mental health status between frontier-line and non-frontier-line medical staff. This study used the Child PTSD Symptom Scale, the Self-Rating Depression Scale, the Self-Rating Anxiety Scale and the Connor-Davidson Resilience Scale to examine the PTSD, depression, anxiety and resilience among 162 frontier-line medical workers and 163 non-frontier-line medical workers in China. The results showed that all negative factor scores of non-frontier-line medical staff seemed to be worse than those of frontier-line medical staff, and the positive factor scores were the opposite through descriptive analysis, independent sample t-test and Chi-square test. Some psychological effects and theories were used to explain this phenomenon. Intervention suggestions for medical staff and future research directions were discussed.