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      研究隊伍
      沈芳 健康與遺傳心理學(xué)研究室副研究員
      電  話(huà):
      電子郵件:shenf@psych.ac.cn
      傳  真:
      課題組網(wǎng)站:
      郵政編碼:100101
      通訊地址:北京市朝陽(yáng)區林萃路16號院中科院心理所
      簡(jiǎn)歷

      2004.09-2008.07,遼寧師范大學(xué),生命科學(xué)學(xué)院,生物技術(shù)專(zhuān)業(yè),學(xué)士

      2008.09-2013.07,北京大學(xué),神經(jīng)科學(xué)研究所,藥物成癮方向,博士

      2013.07-2015.12,中國科學(xué)院心理研究所,健康與遺傳心理學(xué)研究室,博士后

      2016.01-至今,中國科學(xué)院心理研究所,健康與遺傳心理學(xué)研究室,助理研究員

      研究領(lǐng)域

      以大鼠、樹(shù)鼩為主要動(dòng)物模型,通過(guò)小動(dòng)物內窺成像、行為藥理、電生理及分子生物學(xué)等技術(shù)手段,研究藥物成癮的腦機制;以及從情緒和認知角度研究抑郁癥的神經(jīng)機制及抗抑郁藥物的比較及篩選。

      社會(huì )任職
      獲獎及榮譽(yù)
      代表論著(zhù)

      1)Fang Shen, Keke Qi, Ying Duan, Yonghui Li, Jing Liang, Xiaolu Meng, Ming Li, Nan Sui*. Differential effects of clomipramine on depression-like behaviors induced by the chronic social defeat paradigm in tree shrews [J]. Journal of Psychopharmacology, 2018, 32(10): 1141-1149.

      2)Xingyue Wang, Yanhua Qiao, Zhonghua Dai, Nan Sui, Fang Shen, Jianjun Zhang, Jing Liang*. Medium spiny neurons of the anterior dorsomedial striatum mediate reversal learning in a cell-type-dependent manner [J]. Brain Structure and Function, 2018: 1-16.

      3)Fang Shen#, Shubo Jin#, Ying Duan, Jing Liang, Meng Zhang, Fengze Jiang, Nan Sui*. Distinctive changes of L-type calcium channels and dopamine receptors in the dorsomedial and dorsolateral striatum after the expression of habitual cocaine-seeking behaviour in rats [J]. Neuroscience, 2018, 370: 139-147.

      4)Fang Shen#, Xuewei Wang#, Feifei Ge, Yijing Li, Cailian Cui*. Essential role of the NO signaling pathway in the hippocampal CA1 in morphine-associated memory depends on glutaminergic receptors [J]. Neuropharmacology, 2016, 102: 216-228.

      5)Xiaolu Meng, Fang Shen*, Chunlu Li, Yonghui Li, Xuewei Wang. Depression-like behaviors in tree shrews and comparison of the effects of treatment with fluoxetine and carbetocin [J]. Pharmacology Biochemistry and Behavior, 2016, 145: 1-8.

      6)Ying Duan#, Fang Shen#, Tingting Gu, Nan Sui*. Addiction: from context-induced hedonia to appetite, based on transition of micro-behaviors in morphine abstinent tree shrews [J]. Frontiers in Psychology, 2016, 7: 816.

      7)Chong Qi, Xinjuan Wang, Feifei Ge, Yijing Li, Fang Shen, Jungai Wang, Cailian Cui*. mGluR5 in the nucleus accumbens shell regulates morphine-associated contextual memory through reactive oxygen species signaling [J]. Addict Biol, 2015, 20(5):927-40.

      8)Fang Shen#, Ying Duan#, Shubo Jin, Nan Sui*. Varied behavioral responses induced by morphine in the tree shrew: a possible model for human opiate addiction [J]. Frontiers in behavioral neuroscience, 2014, 8: 333.

      9)Fang Shen, Na Wang, Chong Qi, Yi-Jing Li, Cailian Cui*. The NO/sGC/PKG signaling pathway in the NAc shell is necessary for the acquisition of morphine-induced place preference [J]. Behav Neurosci, 2014, 128(4): 446-459.

      10)Fang Shen, Yijing Li, Xiaojing shou, Cailian Cui*. Role of the NO/sGC/PKG signaling pathway of hippocampal CA1 in morphine-induced reward memory [J]. Neurobiol Learn Mem, 2012, 98(2): 130-138.

      11)Xiaohui Xiang, Yin Jiang, Yanjun Ni, Min Fan, Fang Shen, Xuewei Wang, Jisheng Han, Cailian Cui*. Catechol-O-methyltransferase polymorphisms do not play a significant role in pain perception in male Chinese Han population [J]. Physiol Genomics, 2012, 1; 44(5):318-28.

      12)張萌#,沈芳#,段穎,蒙怡蒙,隋南*. 習慣化用藥及其策略轉換的神經(jīng)環(huán)路調控機制[J],生物化學(xué)與生物物理進(jìn)展,2018, 45(10), 1039-1046.

      13)金書(shū)博#,沈芳#,段穎,李鳴,隋南*. 腦內LTCCs在藥物成癮形成過(guò)程中的調控機制. 科學(xué)通報, 2016, 11, 1173-1180.

      14)段穎#,沈芳#,隋南*,強迫性用藥行為的神經(jīng)生物學(xué)機制研究進(jìn)展,科學(xué)通報,60: 1 –7,2015.

      15)沈芳,崔彩蓮*,Homer蛋白與藥物成癮,中國藥物依賴(lài)性雜志,第18卷,第3期,167-171,2009.

       

       

      發(fā)明專(zhuān)利:

      1.維拉帕米抑制長(cháng)時(shí)間戒斷后的用藥渴求及其機制研究,201710496170.7

      2.卡貝縮宮素對樹(shù)鼩抑郁樣行為的治療作用,201710496206.1

       

       

      更多成果信息請見(jiàn):http://ir.psych.ac.cn/shenf@psych.ac.cn

      承擔科研項目情況

      1.中國科學(xué)院心理健康重點(diǎn)實(shí)驗室自主研究項目,KLMH2018ZG05,背側紋狀體調控可卡因覓藥行為的腦環(huán)路機制,2018.04-2021.04,6萬(wàn)元,在研,主持。

      2.國家自然科學(xué)基金青年項目,31500893,樹(shù)鼩伏隔核LTCCs調控可卡因渴求的亞型特異性及其分子機制,2016.01-2018.12,23.9萬(wàn)元,已結題,主持。

      3.心理所青年人才科研啟動(dòng)項目,Y6CX221007,樹(shù)鼩伏隔核內D1R-LTCCs信號通路調控可卡因復吸的機制,2017.01-2018.12,10萬(wàn)元,已結題,主持。

      4.中國博士后科學(xué)基金,2014M550809,應用近靈長(cháng)類(lèi)動(dòng)物樹(shù)鼩探索嗎啡成癮記憶的腦機制,2014.01-2015.12,5萬(wàn)元,已結題,主持。

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