伊人丁香狠狠色综合久久,日韩欧美精品综合久久,亚洲精品老司机综合影院,成人免费一级在线播放

      伊人丁香狠狠色综合久久,日韩欧美精品综合久久,亚洲精品老司机综合影院,成人免费一级在线播放

      研究隊伍
      郭黎媛 健康與遺傳心理學(xué)研究室副研究員
      電  話(huà):010-64855841
      電子郵件:guoly@psych.ac.cn
      傳  真:010-64855841
      課題組網(wǎng)站:http://bioinfo.psych.ac.cn
      郵政編碼:100101
      通訊地址:北京市朝陽(yáng)區林萃路16號院中科院心理所
      簡(jiǎn)歷
      2016.3-至今, 副研究員,中國科學(xué)院心理研究所
      2009.7-2016.2,助理研究員,中國科學(xué)院心理研究所
      2004.9-2009.7,生物化學(xué)與分子生物學(xué)博士,北京大學(xué)醫學(xué)部基礎醫學(xué)院生物化學(xué)與分子生物學(xué)系。導師為李剛教授。
      1999.9-2004.7,醫學(xué)學(xué)士,山西醫科大學(xué)第二臨床醫學(xué)院。
      研究領(lǐng)域

      研究經(jīng)歷:
      1.人類(lèi)全基因組范圍內變異位點(diǎn)調控功能分析
      2.慢性應激環(huán)境下基因表達調控網(wǎng)絡(luò )的構建與分析。
      3.重度抑郁癥多層次知識庫的構建與開(kāi)發(fā)。
      4.GWAS分析平臺ICSNPathway生物學(xué)意義闡述。
      5.淋巴細胞阿片類(lèi)受體功能研究。
      6.猴免疫缺陷病毒Nef蛋白功能研究。

      研究興趣:
      1. 精神神經(jīng)疾病遺傳信息工具平臺的開(kāi)發(fā);
      2. 精神神經(jīng)疾病發(fā)生發(fā)展過(guò)程中基因環(huán)境交互作用的機制;
      3. 基因表達調控網(wǎng)絡(luò )在精神神經(jīng)中的作用機制研究。

      社會(huì )任職
      獲獎及榮譽(yù)
      代表論著(zhù)

      1. Guo, L.Y*., Jin, B*., Zhang, Y.D. and Wang, J#. (2020) Identification of a missense ARSA mutation in metachromatic leukodystrophy and its potential pathogenic mechanism. Mol Genet Genom Med.

      2. Guo, L.Y.*, Lin, W., Zhang, Y.D. and Wang, J#. (2020) A Systematic Analysis Revealed the Potential Gene Regulatory Processes of ATRA-Triggered Neuroblastoma Differentiation and Identified a Novel RA Response Sequence in the NTRK2 Gene. Biomed Res Int, 2020.

      3. Wu, M.S*., Fang, K.C*., Wang, W.X., Lin, W., Guo, L.Y.# and Wang, J#. (2019) Identification of key genes and pathways for Alzheimer’s disease via combined analysis of genome-wide expression profiling in the hippocampus. Biophysics Reports.

      4. Guo, L.Y.*, Lin, W., Zhang, Y.D., Li, W.H. and Wang, J#. (2019) BEST: a web server for brain expression Spatio-temporal pattern analysis. Bmc Bioinformatics, 20.

      5. Guo, L.Y.*# and Wang, J.*# (2018) rSNPBase 3.0: an updated database of SNP-related regulatory elements, element-gene pairs and SNP-based gene regulatory networks. Nucleic Acids Res, 46, D1111-D1116.

      6. Qu, S.S*., Du, Y., Chang, S.H., Guo, L.Y., Fang, K.C., Li, Y.Z., Zhang, F.C., Zhang, K.L. and Wang, J#. (2017) Common variants near IKZF1 are associated with primary Sjogren's syndrome in Han Chinese. Plos One, 12.

      7. Wang, J.L*., Qu, S.S., Wang, W.X., Guo, L.Y., Zhang, K.L., Chang, S.H#. and Wang, J.# (2016) A combined analysis of genome-wide expression profiling of bipolar disorder in human prefrontal cortex. J Psychiatr Res, 82, 23-29.

      8. Guo, L.Y.*, Du, Y.*, Qu, S.S. and Wang, J#. (2016) rVarBase: an updated database for regulatory features of human variants. Nucleic Acids Res, 44, D888-D893.

      9. Zhang, K.L., Chang, S.H., Guo, L.Y. and Wang, J#. (2015) I-GSEA4GWAS v2: a web server for functional analysis of SNPs in trait-associated pathways identified from genome-wide association study. Protein Cell, 6, 221-224.

      10. Guo, L.Y.*#, Du, Y. and Wang, J#. (2015) Network analysis reveals a stress-affected common gene module among seven stress-related diseases/systems which provides potential targets for mechanism research. Sci Rep-Uk, 5.

      11. Guo, L.Y.*, Du, Y., Chang, S.H., Zhang, W.N. and Wang, J#. (2014) Applying Differentially Expressed Genes From Rodent Models of Chronic Stress to Research of Stress-Related Disease: An Online Database. Psychosom Med, 76, 644-649.

      12. Guo, L.Y.*, Du, Y.*, Chang, S.H., Zhang, K.L. and Wang, J.# (2014) rSNPBase: a database for curated regulatory SNPs. Nucleic Acids Res, 42, D1033-D1039.

      13. Zhang, W.N.*, Chang, S.H., Guo, L.Y., Zhang, K.L. and Wang, J#. (2013) The neural correlates of reward-related processing in major depressive disorder: A meta-analysis of functional magnetic resonance imaging studies. J Affect Disorders, 151, 531-539.

      14. Guo, L.Y.*, Zhang, W.N.*, Chang, S.H.*, Zhang, L.Y., Ott, J. and Wang, J# (2012) MK4MDD: A Multi-Level Knowledge Base and Analysis Platform for Major Depressive Disorder. Plos One, 7.

      15. Zhang, K.L., Chang, S.H., Cui, S.J., Guo, L.Y., Zhang, L.Y. and Wang, J.# (2011) ICSNPathway: identify candidate causal SNPs and pathways from genome-wide association study by one analytical framework. Nucleic Acids Res, 39, W437-W443.
       

      更多成果信息請見(jiàn):http://ir.psych.ac.cn/guoly@psych.ac.cn

      承擔科研項目情況

      1.國家自然科學(xué)基金青年項目(81201046):慢性溫和應激環(huán)境下BALB/c小鼠全腦基因表達調控網(wǎng)絡(luò )構建與分析
      2.中國科學(xué)院心理研究所(Y0CX411S01):重癥抑郁障礙多學(xué)科層面生物指標數據庫。
      3.中國科學(xué)院心理研究所,心理健康院重點(diǎn)實(shí)驗室,自主課題項目:小鼠前額皮質(zhì)慢性應激相關(guān)基因調控網(wǎng)絡(luò )分析。

      軟件下載