2016- 中國科學(xué)院心理研究所 研究員
2005-2016 中國科學(xué)院心理研究所 副研究員，碩士生導師
期間2010年02-10月 費城兒童醫院兒童研究中心 訪(fǎng)問(wèn)學(xué)者
期間2014年- 博士生導師
2000-2004 中國科學(xué)院心理研究所生物心理學(xué)專(zhuān)業(yè)，獲博士學(xué)位
1998-2005 中國科學(xué)院心理研究所研究實(shí)習員、助理研究員
1994-1997 沈陽(yáng)藥科大學(xué)藥物分析專(zhuān)業(yè)，獲碩士學(xué)位
1990-1994 新疆醫學(xué)院藥學(xué)系，獲學(xué)士學(xué)位

2017年－   中國心理學(xué)會(huì )生理心理學(xué)專(zhuān)業(yè)委員會(huì ) 副主任委員

2017年－   中國神經(jīng)科學(xué)學(xué)會(huì )應激神經(jīng)生物學(xué)分會(huì ) 副主任委員

2013年－   中國心理衛生協(xié)會(huì )心身醫學(xué)專(zhuān)業(yè)委員會(huì ) 委員

2015年－   中國動(dòng)物學(xué)會(huì )動(dòng)物行為學(xué)分會(huì )理事會(huì ) 常務(wù)理事

2015年－   中國生理學(xué)會(huì )應激生理學(xué)專(zhuān)業(yè)委員會(huì ) 委員

2018年－   中國生理學(xué)會(huì )中醫藥腦穩態(tài)專(zhuān)業(yè)委員會(huì ) 委員

Brain and behavior 副主編

Frontiers in Molecular Neuroscience 編審

OBM Neurobiology 編委

Stress and Brain 編委

心理學(xué)報 編委 

代表論著(zhù)（2015-）：

• Xu, Haiyun; Wang, Weiwen; Ellenbroek, Bart; You, Zili. Editorial: Cognitive Dysfunctions in Psychiatric Disorders: Brain-Immune Interaction Mechanisms and Integrative Therapeutic Approaches. Frontiers in Integrative Neuroscience, 2021, 15: 0-649425. 
• Ge, Li-Kun; Hu, Zhuoer; Wang, Weiwen; Siu, Parco M.; Wei, Gao-Xia. Aerobic Exercise Decreases Negative Affect by Modulating Orbitofrontal-Amygdala Connectivity in Adolescents. Life-Basel, 2021, 11(6): 0-577. 
• Keliang Pang, Richeng Jiang, Wei Zhang, Zhengyi Yang, Lin-Lin Li, Makoto Shimozawa, Simone Tambaro, Johanna Mayer, Baogui Zhang, Man Li, Jiesi Wang, Hang Liu, Ailing Yang, Xi Chen, Jiazheng Liu, Bengt Winblad, Hua Han, Tianzi Jiang, Wang Weiwen, Per Nilsson, Wei Guo, & Lu Bai* (2021). An App knock-in rat model for Alzheimer’s disease exhibiting Aβ and tau pathologies, neuronal death and cognitive impairments. Cell Research, 32, 157– 175. 
• Xu H., Zhang XY, Wang WW, Wang JS. Hydroxychloroquine increased psychiatric-like behaviors and disrupted the expression of related genes in the mouse brain. Frontiers in Pharmacology. 2021, doi:  10.3389/fphar.2021.633112
• Hang Xu, Jiesi Wang, Haiyang Jing, Bart Ellenbroek, Feng Shao, Weiwen Wang*. mPFC GABAergic  transmission mediated the role of BDNF signaling in cognitive impairment but not anxiety induced by adolescent social stress, Neuropharmacology, 2021, 184,108412.
• HaoZhou, Jiesi Wang, Yu Zhang, Feng Shao* and Weiwen Wang*. The Role of Microglial CX3CR1 in Schizophrenia-Related Behaviors Induced by Social Isolation. Frontiers in Integrative Neuroscience. September 2020, Volume14: Article 551676.
• Qiong Wang, Yingjuan Liu, Jianxu Zhang* and Weiwen Wang*. Corticotropin-Releasing Factor Receptors in the Locus Coeruleus Modulate the Enhancement of Active Coping Behaviors Induced by Chronic Predator Odor Inoculation in Mice. Frontiers in Psychology. 2020, 10: 3028.
• Yuanyuan Xin, Zhuxi Yao, Weiwen Wang, Yuejia Luo, Andr_e Aleman and Jianhui Wu. Recent life stress predicts blunted acute stress response and the role of executive control. STRESS. 2020, VOL. 23（3）: 359–367.
• Yu Zhang, Hang Xu, Jiesi Wang, Fengyan Ren,b, Feng Shao, Bart Ellenbroek, Wenjuan Lin, Weiwen Wang. (2019). Transient upregulation of immune activity induced by adolescent social stress is involved in cognitive deficit in adult male mice and early intervention with minocycline. Behavioral Brain Research, 374, 112136, doi.org/10.1016/j.bbr.2019.112136

• Yu Zhang#, Hang Xu#, Fan Zhang, Feng Shao, Bart Ellenbroek, Jiesi Wang*, Weiwen Wang*. (2019). Deficiencies of microglia and TNFa in the mPFC-mediated cognitive inflexibility induced by social stress during adolescence. Brain, behavior and immunity, 79, 256-266.
• Wang, W., Wang, L*., Xu, H., Cao, C., Liu, P., Luo, S., . . . Zhang, X. (2019). Characteristics of pro- and anti-inflammatory cytokines alteration in PTSD patients exposed to a deadly earthquake. J Affect Disord, 248, 52-58. doi: 10.1016/j.jad.2019.01.029
• Man Li; Weiwen Wang#; Lan Sun; Wei Du; Hao Zhou; Feng Shao*, (2019). Chronic clozapine treatment improves the alterations of prepulse inhibition and BDNF mRNA expression in the medial prefrontal cortex that are induced by adolescent social isolation. Behavioural Pharmacology. 30(4):311–319
• Xin, Y., Yao, Z., Wang, W., Luo, Y., Aleman, A., Wu, J. (2019). Recent life stress predicts blunted acute stress response and the role of executive control. Stress, 12:1-9. doi.org/10.1080/10253890.2019.1687684
• Zheng Chen, Quan Zhang, Shenghuo Chen, Weiwen Wang, Guoxiong Liu, Huihua Deng. (2019).  Determination, intercorrelation and intraindividual stability of five steroids  in hair, saliva and urine among chinese college students. Steroids, 149, 108418
• Li, M., Xu, H., & Wang, W. * (2018). An Improved Model of Physical and Emotional Social Defeat: Different Effects on Social Behavior and Body Weight of Adolescent Mice by Interaction With Social Support. Frontiers in Psychiatry, 9(688). doi: 10.3389/fpsyt.2018.00688
• Hang Xu#, Jiesi Wang#, Ke Zhang, Mei Zhao, Bart Ellenbroek, Feng Shao*, Weiwen Wang*. Effects of adolescent social stress and antidepressant treatment on cognitive inflexibility and Bdnf epigenetic modifications in the mPFC of adult mice. Psychoneuroendocrinology, 2018, 88: 92-101.
• Zhang, Q., Chen, Z., Chen, S., Yu, T., Wang, J., Wang, W., & Deng, H. (2018). Correlations of hair level with salivary level in cortisol and cortisone. Life Sci, 193, 57-63. doi: 10.1016/j.lfs.2017.11.037
• Qiong Wang, Feng Shao and Weiwen Wang*. Region-Dependent Alterations in Cognitive Function and ERK1/2 Signaling in the PFC in Rats after Social Defeat Stress. Neural Plasticity, 2018, doi.org/10.1155/2018/9870985
• Sun, Lan, Min, Li, Li, Man, Shao, Feng*, & Wang, Weiwen* (2018). Transcriptomic analysis reveals oxidative phosphorylation activation in an adolescent social isolation rat model. BRAIN RESEARCH BULLETIN,142,304-312.
• Bart A. Ellenbroek, Weiwen Wang. The Translational Umbrella - A Novel Approach to the Study of the Biological Basis of Mental Health. OBM Neurobiology, 2018; 2(1), doi: 10.21926/obm.neurobiol.1801008

• Lan Sun, Li Min, Hao Zhou, Man Li, Feng Shao*, Weiwen Wang*, Adolescent social isolation affects schizophrenia-like behavior and astrocyte biomarkers in the PFC of adult rats. Behav Brain Res, 2017, 333: p. 258-266.
• Zhang, Y., Shao, F., Wang, Q., Xie, X., Wang, W.W. * (2017). Neuroplastic correlates in the mPFC underlying the impairment of stress-coping ability and cognitive flexibility in adult rats exposed to chronic mild stress during adolescence. Neural Plasticity, 10. doi: 10.1155/2017/9382797
• Jenny Berrío, Weiwen Wang, Bart A. Ellenbroek. Perspectives on the Neurobiology of Antipsychotic Drugs in Psychiatric Disorders. OBM Neurobiology.2017,1(1): doi:10.21926/obm.neurobiol.1701001
• 徐 航,陳煥新，王瑋文*. GABA 能系統在應激誘發(fā)的抑郁癥中的作用.心理科學(xué)進(jìn)展. 2017, 25(12): 2075–2081
• 張 瑜,林文娟,王瑋文*. 中樞免疫失衡與認知功能障礙：聚焦TNF的作用.心理科學(xué)進(jìn)展. 2017, 25(12): 2036–2042
• 王瓊,王瑋文*,李曼,杜偉,邵楓*.阻斷內側前額葉皮質(zhì)TrkB受體對大鼠認知和海馬BDNF表達的影響. 2016, 48(5): 509-517.
• Xu, H. #, Zhang, Y. #, Zhang, F., Yuan, S., Shao, F., & Wang, W. * (2016). Effects of Duloxetine Treatment on Cognitive Flexibility and BDNF Expression in the mPFC of Adult Male Mice Exposed to Social Stress during Adolescence. Frontiers in Molecular Neuroscience, 9, 95.
• Zhang, F.#, Yuan, S. #, Shao, F., & Wang, W.W. * (2016). Adolescent social defeat induced alterations in social behavior and cognitive flexibility in adult mice: effects of developmental stage and social condition. Frontiers in Behavioral Neuroscience, 10, 149,1-11.
• Li, M., Du, W., Shao, F. *, Wang, W.W. * (2016). Cognitive dysfunction and epigenetic alterations of the BDNF gene are induced by social isolation during early adolescence. Behav Brain Res, 313, 177-183.
• Mwanza, C., Chen, Z., Zhang, Q., Chen, S., Wang, W. W., & Deng, H.H. * (2016). Simultaneous HPLC-APCI-MS/MS quantification of endogenous cannabinoids and glucocorticoids in hair. Journal of Chromatography B, 1028, 1-10.
• 張權，陳崝，王瑋文，鄧慧華.創(chuàng )傷后應激障礙患者的HPA軸功能變化的時(shí)間序列特征. 《心理科學(xué)進(jìn)展》, 2016,24(4):536-546
• Tian Yu, Hang Xu, Weiwen Wang, Shifei Li, Zheng Chen, Huihua Deng*. Determination of endogenous corticosterone in rodent’s blood, brainand hair with LC–APCI–MS/MS. Journal of Chromatography B, 2015, 1002: 267–276
• Qiong Wang, Feng Shao*, Weiwen Wang*. Maternal separation produces alterations of forebrain brain-derived neurotrophic factor expression in differently aged rats. Frontiers in Molecular Neuroscience. 2015，8：49：1-9
• Weiwen Wang, Huihua Deng, Li Wang*, Chengqi Cao,Hang Xu, Jianxin Zhang. Hair cortisone level is associated with PTSD’s dysphoric arousal symptoms in highly traumatized Chinese females. Journal of affective disorders, 2015, 182, 18-22
• Yan Jin, Bin Luo, Yan-Yan Su,Xin-Xing Wang, Liang Chen*, Ming, Wang, Wei-Wen*, Lin Chen*. Sodium salicylate suppresses GABAergic 1 inhibitory activity in neurons of rodent dorsal raphe nucleus. Plos one, 2015, 10(5): e0126956.
• Qiong Wang, Man Li, Wei Du, Feng Shao*, Weiwen Wang*. The different effects of maternal separation on spatial learning and reversal learning in rats. Behavioural Brain Research, 2015, 280: 16–23.

譯/編著(zhù)作：
1、王福順等，情緒心理學(xué)(第四章情緒的生理機制)(全國高等學(xué)校教材國家衛生健康委員會(huì )“十三五”規劃教材). 人民衛生出版社，2018
2、行為的生物心理學(xué)基礎，蘇彥捷等著(zhù)，應激與健康（第九章）
3、詹姆斯.卡拉特著(zhù)，蘇彥捷等譯，生物心理學(xué) (第十版)(第十章).人民郵電出版社，2011.

專(zhuān)利和軟著(zhù)：
1、 王瑋文, 張偉, 井海洋, & 王杰思. (2020). 一種基于觸屏操作箱視覺(jué)空間配對學(xué)習的實(shí)驗與分析方法. CN111990971A.（發(fā)明專(zhuān)利）CN202010912439.7
2、 中國科學(xué)院心理研究所（王瑋文，張偉，井海洋）. 基于一種觸屏操作箱內的視覺(jué)空間配對學(xué)習過(guò)程的數據提取和精細化分析軟件 V1.0. 軟件著(zhù)作權登記證書(shū). 2020SR1162221.
3、 王瑋文，張瑜，任鳳燕；米諾環(huán)素用于制備精神疾病相關(guān)認知功能障礙早期干預藥物的用途（CN110151772A）CN201910401486.2
4、 王瑋文；林文娟；邵楓；楊震.一種多水平客觀(guān)測定動(dòng)物學(xué)習能力的行為實(shí)驗系統和方法. 中國, 2005 1 0086956.9（發(fā)明專(zhuān)利）
5、 王瑋文；林文娟；邵楓；楊震.一種動(dòng)物學(xué)習能力的行為測試用的水迷宮.中國, 200520142005.4（實(shí)用新型
6、 王瑋文; 梁云明;黃景新.一種適于同時(shí)蒸發(fā)多個(gè)液態(tài)生化樣品的干燥裝置FPI03034（發(fā)明專(zhuān)利）

更多成果信息請見(jiàn)：http://ir.psych.ac.cn/wangww@psych.ac.cn

1. 國家自然科學(xué)基金項目面上項目，“小膠質(zhì)細胞在青少期創(chuàng )傷后不同情緒障礙發(fā)展風(fēng)險中的異質(zhì)性作用及其神經(jīng)可塑性機制”（82071517），2021.1-2024.12，主持
2. 國家重點(diǎn)研發(fā)計劃政府間國際科技創(chuàng )新合作重點(diǎn)專(zhuān)項課題，“神經(jīng)營(yíng)養因子參與神經(jīng)退行性疾病的環(huán)路及機制研究”（2017YFE0126500），2019.8-2022,7，課題負責
3. 中國科學(xué)院心理研究所開(kāi)放課題，“AMPA受體GluA1亞基在創(chuàng )傷后應激障礙負性情緒的發(fā)生及靶向干預中的作用研究”,2021.1-2023.12，合作者
4. 國家自然科學(xué)基金項目面上項目，“青少期應激誘發(fā)抑郁癥認知功能障礙的中樞免疫機制及干預新策略”（31771217）,2018.1-2021.12, 61萬(wàn)，主持
5. 心理健康院重點(diǎn)實(shí)驗室重點(diǎn)課題，“注意缺陷多動(dòng)障礙模型大鼠內側前額皮層-伏隔核環(huán)路在決策沖動(dòng)性中的作用機制”（KLMH2020K06），2020.09-2022.09，合作者
6. 國家自然科學(xué)基金項目面上項目，“青少期早期社會(huì )應激對抑郁樣行為和前額葉GABA能系統的影響及其關(guān)系研究”（81471122）, 2015/01-2018/12, 主持
7. 中國科學(xué)院“十二五”重點(diǎn)部署項目,“中國特定人群的心理與社會(huì )行為研究”子課題“ 創(chuàng )傷后應激障礙臨床異質(zhì)性的心理神經(jīng)機制” KSZD-EW-Z-008）,2013/01-2016/12，參與
8. 心理健康院重點(diǎn)實(shí)驗室重點(diǎn)課題，“創(chuàng )傷后應激障礙患者HPA軸功能變化的時(shí)間序列特征”（KLMH2015K01），2014.1-2016.12，合作者
9. 心理健康院重點(diǎn)實(shí)驗室重點(diǎn)課題，“早年創(chuàng )傷誘導快感缺失樣抑郁行為的獎賞環(huán)路機制”，2016/01-2018/12，合作者
10. 中國科學(xué)院心理研究所自主部署科研項目 “重性抑郁癥的功能分型及神經(jīng)基礎研究”（Y5CX152008），2015.11-2017.11，主要成員
11. 國家自然科學(xué)基金項目重大研究計劃培育項目，“應激影響青少年情緒和認知發(fā)展的BDNF調控機制及早期干預研究”（91132728）, 2012/01-2014/12, 主持