精神分裂癥是一種復雜的精神疾病，該疾病會(huì )導致大范圍的神經(jīng)認知、情感和神經(jīng)發(fā)育異常。神經(jīng)軟體征(NSS)被認為是最具前景的精神分裂癥內表型之一。 中國科學(xué)院心理健康重點(diǎn)實(shí)驗室的陳楚僑研究員帶領(lǐng)神經(jīng)心理學(xué)與應用認知神經(jīng)科學(xué)(NACN)團隊提供了大量關(guān)于NSS對精神分裂癥的敏感性、可靠性和特異性的證據。然而，目前還不清楚NSS與精神分裂癥腦網(wǎng)絡(luò )異常之間的關(guān)系。  

　　在最近的一項研究中，陳楚僑和研究團隊的孔麗博士后以及國際合作伙伴使用圖論方法，對101名首發(fā)精神分裂癥患者的潛在大腦結構網(wǎng)絡(luò )進(jìn)行了深入研究。 

　　研究者進(jìn)行了基于灰質(zhì)形態(tài)計量學(xué)的結構網(wǎng)絡(luò )分析以及與NSS相關(guān)聯(lián)的分析，將患者分為高水平和低水平的NSS組，并檢查了他們的局部以及全局腦網(wǎng)絡(luò )特征。 

　　研究表明，兩組患者在全局腦網(wǎng)絡(luò )特征上沒(méi)有顯著(zhù)差異。隨后的局部網(wǎng)絡(luò )特征分析發(fā)現NSS與眶下額葉皮層、顳中皮層、海馬體、眶上皮層、杏仁核、小腦的介數中心度相關(guān)。全局腦網(wǎng)絡(luò )分析結果進(jìn)一步表明，NSS與包括額上內側皮質(zhì)、顳上、中皮層、中央后皮質(zhì)、杏仁核和小腦在內的中樞節點(diǎn)分布有關(guān)。這些區域與被認為是精神分裂癥患者臨床和行為表現原因的皮質(zhì)-皮質(zhì)下-小腦回路異常相一致。   

　　陳楚僑的團隊及其合作者正在結合NSS的行為測量和神經(jīng)影像測量進(jìn)一步考查精神分裂癥NDD在腦結構和功能上的異常表現，以期更好地理解精神分裂癥的發(fā)病機制。  

　　該研究受?chē)抑攸c(diǎn)研究開(kāi)發(fā)項目、“科技北京”領(lǐng)軍人才培養工程、中國科學(xué)院心理健康重點(diǎn)實(shí)驗室、心理所、國家自然科學(xué)基金的資助。  

　　本文已在線(xiàn)發(fā)表于Schizophrenia Bulletin： 

　　論文信息： 

　　Kong, L., Herold, C. J., Cheung, E. F. C., Chan, R. C. K.*, Johannes Schr？der. (2019). Neurological soft signs and brain network abnormalities in schizophrenia. Schizophrenia Bulletin, https://doi.org/10.1093/schbul/sbz118  

　　相關(guān)論文： 

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　　Chan, R. C. K.* (2011). Consortium for the Human Information and Neurocognitive Endophenotype (CHINE) in mainland China: An example from neurological soft signs for neuropsychiatric disorders. Chinese Science Bulletin, 56(32), 3409-3415. 

　　Chan, RCK*, Huang, J, Zhao, Q, Wang, Y, Lai, YY, Hong, N., Shum, DHK, Cheung, EFC, Yu, X, Dazzan P. (2015). Prefrontal cortex connectivity dysfunction in performing the Fist-Edge-Palm task in patients with first-episode schizophrenia and non-psychotic first-degree relatives. NeuroImage: Clinical. 9, 411–417  

　　Zhao, Q., Li, Z., Huang, J., Yan, C., Dazzan, P., Pantelis, C., Cheung, E. F. C., Lui, S. S. Y., Chan, R. C. K.*. (2014). Neurological soft signs are not “soft” in brain structure and functional networks: Evidence from ALE meta-analysis. Schizophrenia Bulletin, 40(3): 626-641. 

　　Chan, R. C. K.*, Dai, S., Lui, S. S. Y., Ho, K K. Y., Hung, K. S. Y., Wang, Y., Geng, F. L., Li., Z., Cheung, E. F. C. (2015). Re-visiting the nature and relationships between neurological signs and neurocognitive functions in first-episode schizophrenia: An invariance model across time. Scientific Reports, 5: 11859. 

　　Chan, R. C. K*, Geng, F. L., Lui, S. S. Y., Wang, Y., Ho, K K. Y., Hung, K. S. Y., Gur, R. E., Gur, R. C., Cheung, E. F. C. (2015). Course of neurological soft signs in first-episode schizophrenia: Relationship with negative symptoms and cognitive performances. Scientific Reports, 5:11053   

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